ALKALINE PHOSPHATASE; Total serum alkaline phosphatase (ALP) as a predictor of bone metastasis among patients having carcinoma breast at a tertiary care hospital

摘要

Background: This study was carried out to determine the role of total serumalkaline Phosphatase in bone metastasis among patients of breast cancer. Setting; Departmentof Surgery, Nishtar Medical University, Multan in collaboration with breast clinic MINAR. StudyDuration; January 2016 to June 2017 Subjects and methods; It was a retrospective studycarried out at breast clinic MINAR, Multan. The medical record of the female patients havingbreast cancer aged 25 to 70 years (who presented from January 2016 to June 2017) wasscrutinized. All the registered patients during above mentioned period having breast carcinomawith metastatic bone disease, as depicted on bone scan, were taken as index cases. All thecases underwent total serum alkaline Phosphatase estimation. We collected 86 cases for thisresearch study. Primary bone tumours, lymphomas, sarcomas and bone metastasis due toother primary visceral malignancies were excluded. All the required data were entered andanalyzed using computer program SPSS version 20.0. Results; The mean age of the breastcancer patients was 46.51 ± 11.11 years (ranging from 25 – 70 years). Eighty four (97.7%) weremarried. All the patients presented with lump breast. Only 3 (3.5%) of the cases gave familyhistory of breast cancer and history of contraceptive pills was positive in 4 (3.7%) of the cases.History of breast feeding was positive in 63 (73.3%) of the cases. Mean age at menarche was13.21± 0.896 years in our study cases. Mean age at menopause in our study was 46.86 ±5.66 years. Total serum alkaline Phosphatase was raised in 27 (31.4%) cases. Only 6 (6.9%) ofthe cases showed its level more than 500 IU/L. Conclusion; Our study results don’t favor totalserum alkaline Phosphatase estimation as biological marker of bone metastasis among breastcancer patients. Bone scan is more reliable and hence be employed for detection of bonemetastasis. Further studies on bone ALP and total ALP estimation are required to generatefurther evidence on this subject.