首页> 外文期刊>The Open Respiratory Medicine Journal >Correlation of Plasma Protein Carbonyls and C-Reactive Protein with GOLD Stage Progression in COPD Patients
【24h】

Correlation of Plasma Protein Carbonyls and C-Reactive Protein with GOLD Stage Progression in COPD Patients

机译:COPD患者血浆蛋白羰基和C反应蛋白与GOLD分期的相关性

获取原文
       

摘要

Oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). To investigate the correlation between the progression of COPD and plasma biomarkers of chronic inflammation and oxidative injury, blood samples were obtained from healthy volunteers (HV, n = 14) and stabilized COPD patients. The patients were divided into three groups according to their GOLD stage (II, n = 34; III, n = 18; IV, n = 20). C-reactive protein (CRP), protein carbonyls (PC), malondialdehyde (MDA), susceptible lipoperoxidation of plasma substrates (SLPS), and myeloperoxidase activity (MPO) were measured. The plasma concentration of SLPS was measured as the amount of MDA generated by a metal ion-catalyzed reaction in vitro. PC, SLPS, and CPR were increased significantly (p < 0.001) in COPD patients when compared to HV. MDA concentrations and MPO activities were not significantly different from those of the HV group. In conclusion, increased oxidation of lipids and proteins resulting in a progressive increase in the amount of total plasma carbonyls and oxidative stress the presence of oxidative stress during COPD progression, concomitant with an increased oxidation of lipids and proteins resulting in a progressive and significant increase in the amount of total carbonyls formed from lipid-derived aldehydes and direct amino acid side chain oxidation in plasma, may serve as a biomarker and independent monitor of COPD progression and oxidative stress injury.
机译:氧化应激在慢性阻塞性肺疾病(COPD)的发病机理中起着重要作用。为了研究COPD的进展与慢性炎症和氧化损伤的血浆生物标志物之间的相关性,从健康志愿者(HV,n = 14)和稳定的COPD患者中获取血液样本。根据患者的黄金时期将其分为三组(II,n = 34; III,n = 18; IV,n = 20)。测量了C反应蛋白(CRP),蛋白羰基(PC),丙二醛(MDA),血浆底物的易脂质过氧化(SLPS)和髓过氧化物酶活性(MPO)。将SLPS的血浆浓度测量为金属离子催化体外反应产生的MDA量。与HV相比,COPD患者的PC,SLPS和CPR显着增加(p <0.001)。 MDA浓度和MPO活性与HV组无显着差异。总之,脂质和蛋白质的氧化增加导致血浆总羰基含量和氧化应激的逐渐增加,COPD进展过程中存在氧化应激,同时脂质和蛋白质的氧化增加导致脂质和蛋白质的进行性显着增加。血浆中由脂质衍生的醛和直接氨基酸侧链氧化形成的总羰基数量可作为COPD进程和氧化应激损伤的生物标志物和独立监测器。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号