Immunohistochemical expression of p53 in basal cell carcinoma of skin.

摘要

Objectives: To evaluate the immunohistochemical expression of p53 in basal cellcarcinoma of skin. Study Design: It was cross sectional study. Setting: Pathology department ofPakistan Institute of Medical Sciences Hospital, Shaheed Zulfiqar Ali Bhutto Medical University,Islamabad, Pakistan. Period: Six months from July 2015 to January 2016 after approval fromthe Hospital Ethical Committee. Material and Methods: In a descriptive background, 50 caseswere involved in the study. Cases were selected by non-probability consecutive samplingtechnique. Patients of all age group (Males and Females), diagnosed as basal cell carcinoma ofskin by Hematoxylin & Eosin were included in study. Other epithelial tumors of skin, appendagealtumors and metastatic tumors were excluded. Cases were evaluated for expression of tumorsuppressor protein-p53 by immunohistochemical technique applied on formalin-fixed paraffinembeddedblocks. Results: Out of 50 cases, majority of patients were found to be male. Ratioof male to female was 2.6:1. Age range of patient was found between 21-98 years. Mainstreamof the patients were between 41-60 years. Nose was found to be frequently involved site 28(56%) cases. p53 expression was seen in 42 (84%) cases while in 8 (16%) cases p53 expressionwas not seen. Conclusion: It was found that p53 expression rate is very high in basal cellcarcinoma of skin. This high expression of p53 immunoreactivity was explained in terms of itspathogenetic role and mutation in basal cell carcinoma.