Oxidative Stress in Parkinson’s Disease

摘要

Parkinson’s disease (PD) is a progressive, age-related movement disorder, whose neuropathology is characterizedby degeneration of the afferent pigmented neurons of the substantia nigra. Also associated with PD neuropathologyare disrupted iron homeostasis, oxidative stress, and intracellular deposition of alpha-synuclein protein in Lewy bodies.Here we review oxidative stress mechanisms in Parkinson’s disease, with emphasis on the relationship between oxidativestress and alpha-synuclein gene expression.