COMPARISION OF EFFECETS OF STATIN AND NIACIN STATIN COMBANITION, ON APOLIPOPROTEIN-B LEVEL IN HYPERLIPIDEMIC PATIENTS.

摘要

Objectives: Role of niacin in decreasing cardiovascular accidents by loweringthe levels of Apo-B in hyperlipidemic patients. Background: In hyperlipidemia, there are highlevels of atherogenic lipoproteins leading to higher risk of atherosclerotic cardiovascular events.Patients with dyslipidemia use statins as a mainstay of therapy over last many decades. Recentstudies show that apolipoproteins play a major role in formation of atheromatous plaque, thusthere is an urgent need to study the effects of lipid lowering medication on apolipoprotienslevels. Study Design: Cross sectional analytical study. Setting: Sheikh Zayed Hospital Lahore(Department of Biochemistry and Chemical Pathology). Period: 12 weeks from July to Sep2014. Materials and Methods: Recently diagnosed hyperlipidemic patients (n=44) wereselected for the study purpose and divided into two equal groups; A and B. Each group wasgiven different medication. Group A took only statin while group B took a combination of statinand niacin. Blood samples were taken at the start of medication and then after completion of12 week time period. Results: At the start of the treatment there was no significant difference inthe Apo B cholesterol level between the two groups (p value 0.972). However, after the end of12 week duration, there was a significant reduction in the Apo level of group B taking statin andniacin as compared to group A taking statin alone (p value 0.003). Conclusions: Niacin hascardio-protective role when used in combination with niacin.