A Novel In Situ Self-Dissolving Needle Web Based on Medicated CelluloseHollow Fibres with Drug Delivery Features

摘要

Medicated wound dressings incorporate chemicals which have therapeutic value. The objective of this studywas to investigate the in vitro model drug release from a biodegradable needle web, based on medicated cellulosic hollowfibres, which self-dissolve in the presence of aqueous solutions.Cellulose hollow fibres were prepared by a standard dry-wet phase inversion spinning process. Dressings were made usingestablished techniques in the nonwoven industry. Two sets of hollow fibres were filled with different drug solutions:One set contained the enzyme cellulase and the second set was filled with either antibacterial Pseudomonas aeruginosaspecificbacteriophages, or the wound debriding enzyme Krillase?. Both fibre sets were freeze-dried to (i) inactivate thespontaneous biodegradation of the fibres by cellulase and (ii) to preserve the wound healing activities of the biotherapeuticmodel drugs. Needle webs containing different mixing ratios of the two sets of hollow fibres were made. Whereas bacteriophageswere released after rewetting the webs in in-vitro experiments with high burst effect, Krillase? showed a sustaineddrug release over 20 h, which was found to be dependent on the mixing ratio of cellulase versus Krillase?-hollowfibres. Possible release mechanisms and therapeutic benefits are discussed.In summary, needle webs of medicated cellulosic hollow fibres are a new self-dissolving drug delivery system.