Modified Food Selection Improves Obesity-Related Metabolic DisturbancesIndependent from Weight Loss

摘要

Dietary therapy has been shown to be important to reduce weight and other risk factors for CVD if a high-riskpattern is present. We investigated if modified food selection improved obesity-related metabolic disturbance independentlyfrom weight loss in a prospective cohort study. After a comprehensive 4-week residential period which stressedhealthy food, physical training, and stress management, patients were followed for one year. The most common diagnosesbesides obesity were hypertension, type-2 diabetes and dyslipidemia. A dietary questionnaire was completed at the firstvisit and after one year. Weight loss resulted in lower blood glucose (B-Glu) Odds Ratio (OR) = 2.45, p<0.001, serumtriglyceride (S-TG) OR = 2.80, p<0.001 and serum urate (S-Urate) OR = 2.62, p<0.001. With less fat on bread bodyweight was reduced (OR = 2.46, p<0.01), and with less candy S-HDL was increased (OR = 1.72, p<0.01) and S-Urate wasdecreased (OR = 2.10, p<0.001). A decrease in S-Urate was not found associated with more fruit and berries (OR = 0.48p<0.05), less cheese (OR = 0.38, p<0.05) or less milk (OR = 0.50 p<0.05). Less coffee was associated with decreased systolicblood pressure (SBP) OR = 1.85, p<0.05. Modified food selection was associated with improved risk factor levelsindependently from weight loss.