Contribution of Various Dietary Constituents to the Acid Base Status: Interest of Animal Models of Latent Metabolic Acidosis

摘要

Animal models of metabolic acidosis are generally based on drastic treatments and are poorly suitable as modelsof latent metabolic acidosis (LMA). Specific rodent diets have been evaluated as LMA models, together with their responsivenessto dietary alkalinizing factors. Using this model, the possibility to obtain LMA states with moderate levels ofprotein intake was identified, pointing to the critical role of anions in the mineral moiety of the diet. The potential role oflarge intestine fermentations to acid-base control has also been examined with this model.