Human Enterovirus 71 Disease: Clinical Features, Epidemiology, Virology, and Management

摘要

The purpose of this review was to summarize the epidemiology, clinical pictures, and virology of enterovirus71 (EV71) infection. An epidemiological study in Taiwan revealed that the reported incidence of mild cases of hand-footmouthdisease/herpangina (HFMD/HA) varied from year to year; seasonal variations in incidence were observed, with anincidence peak observed during the summer season. The study also showed that different enteroviruses co-circulate in thecommunity, and seroepidemiological studies suggest that children aged less than 4 years old are most susceptible, whileover 50% of the rest of the population is immune. The emergence of the EV71 epidemic in the Asia Pacific region hasbeen associated with the circulation of three genetic lineages (genotype B3, B4, C2) that appear to be undergoing rapidevolutionary changes. EV 71 infection has emerged as an important public problem, causing serious clinical illness and,potentially, death in young children. Vaccine development is recommended for the prevention of EV 71 infection in thefuture.