Successful Direct Adsorption of Lipoproteins (DALI) Apheresis DuringPregnancy in an Omani Woman with Homozygous Familial Hypercholesterolemia

摘要

We report our experience with Direct Adsorption of Lipoproteins (DALI) apheresis in an Omani pregnantwoman affected by homozygous familial hypercholesterolemia. To the best of our knowledge this is the first successfulpregnancy treated with DALI apheresis.The patient had a history of coronary artery disease, supra-aortic valvular stenosis and severe carotid artery disease withright carotid artery stenting. She was on a regular biweekly DALI apheresis since 2008. In May 2013, she becamepregnant and rosuvastatin and ezetimibe were stopped while she continued on DALI apheresis biweekly. This treatmentduring pregnancy was successful with no major complications. The average low-density lipoprotein cholesterol reductionduring therapy was 50%. She spontaneously delivered a healthy male infant (2,400 g) at 37 weeks. We showed that DALIapheresis therapy was safe during pregnancy with a good outcome for both mother and neonate.