A Review of the Efficacy and Safety of NasalezeTM in the Prevention and Management of Allergic Rhinitis

摘要

NasalezeTM is an inert cellulose powder which has been on sale in the UK since 1994 and is used as a remedyfor hay fever. It is applied to the nasal passage where it forms a gelatinous coating, thereby trapping aero-allergens andpreventing the initial allergic response. Some limited clinical studies have been conducted in predominantly adults butalso in children: outcome measures included the reporting of symptoms by volunteers (sneezing, itching, blocked nose,etc) using questionnaires; prevention of symptoms when challenged to aerosolized allergens; concomitant use of rescuemedication and the measurement of inspiratory air flow across the mucosa as well as the release of ECP in nasal washings.The product has been reported to be safe and well tolerated by all volunteers and warrant further investigation inlarger studies.