JMNI Special Issue: Basic Science and Mechanisms of Muscle-Bone Interactions

摘要

A close functional relationship between muscle and bone is observed throughout growth, development, and aging, and this close relationship has provided a foundation for highly influential models of bone adaptation presented by such authors as D’Arcy Thompson, Julius Wolff, Melvin Moss, and Harold Frost. New technologies and experimental approaches now allow scientists to explore the muscle-bone relationship in even greater detail, which has facilitated the discovery of novel mechanisms and pathways at the tissue, cellular, and molecular levels that link muscle and bone anabolism and catabolism. This volume seeks to review some of the recent work in this area, and in so doing highlight new directions and therapeutic strategies for enhancing muscle and bone structure and function