The Role of Consolidation Therapy for Stage III Non-Small Cell Lung Cancer With Persistent N2 Disease After Induction Chemotherapy

摘要

Patient SelectionTreatment and Response AssessmentLocal-Regional and Distant RecurrenceFollow-Up and SurvivalStatistical AnalysisResultsPatient and Treatment CharacteristicsLocal-Regional Failure PatternsDistant Failure PatternsOverall SurvivalOverall Recurrence PatternsPersistent pathologic mediastinal nodal involvement after induction chemotherapy and surgical resection is a negative prognostic factor for stage III-N2 non-small cell lung cancer patients. This population has high rates of local-regional failure and distant failure, yet the effectiveness of additional therapies is not clear. We assessed the role of consolidative therapies (postoperative radiation therapy and chemotherapy) for such patients.MethodsIn all, 179 patients with stage III-N2 non-small cell lung cancer at MD Anderson Cancer Center were treated with induction chemotherapy followed by surgery from 1998 through 2008; 61 patients in this cohort had persistent, pathologically confirmed, mediastinal nodal disease, and were treated with postoperative radiation therapy. Local-regional failure was defined as recurrence at the surgical site or lymph nodes (levels 1 to 14, including supraclavicular), or both. Overall survival was calculated using the Kaplan-Meier method, and survival outcomes were assessed by log rank tests. Univariate and multivariate Cox proportional hazards models were used to identify factors influencing local-regional failure, distant failure, and overall survival.ResultsAll patients received postoperative radiation therapy after surgery, but approximately 25% of the patients also received additional chemotherapy: 9 (15%) with concurrent chemotherapy, 4 (7%) received adjuvant sequential chemotherapy, and 2 (3%) received both. Multivariate analysis indicated that additional postoperative chemotherapy significantly reduced distant failure (hazard ratio 0.183, 95% confidence interval: 0.052 to 0.649, p = 0.009) and improved overall survival (hazard ratio 0.233, 95% confidence interval: 0.089 to 0.612, p = 0.003). However, additional postoperative chemotherapy had no affect on local-regional failure.ConclusionsAggressive consolidative therapies may improve outcomes for patients with persistent N2 disease after induction chemotherapy and surgery.CTSNet classification:10For patients with stage III non-small cell lung cancer (NSCLC), multimodality therapy remains the standard of care. Approximately 10% of all NSCLC cases present as stage IIIA-N2, and for these patients, disease control and overall survival continue to be poor, with 5-year survival rates of 23% [