Recording single-channel activity of inositol trisphosphate receptors in intact cells with a microscope, not a patch clamp

摘要

### IntroductionCytosolic Ca2+ plays a central role as a universal intracellular messenger, controlling many aspects of physiology such as gene expression, electrical excitability, secretion, and synaptic plasticity in virtually all cell types ([Berridge et al., 2000][1]). The rich diversity in