B preceding formation. In the individual who is not losing bone mass, bone remodeling is balanced, with the osteoblast forming the same amount of bone that has been resorbed by the osteoclast. Remodeling in the aging skel- eton, aided and abetted by estrogen deficiency after the menopause, is not balanced, with bone resorption exceed- ing bone formation; as a result, bone loss ensues. The earliest therapeutic attempts to correct this imbalance were focused on inhibiting bone resorption, thus bringing the bone remodeling unit into better balance.
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