The Somatotrope as a Metabolic Sensor: Deletion of Leptin Receptors Causes Obesity

摘要

Andrea Fabbri, Maria-Christina Zennaro, and Bruno Féve The mineralocorticoid receptor (MR) mediates aldosterone- and glu- cocorticoid-induced adipocyte differentiation. Drospirenone (DRSP) is a potent synthetic antimineralocorticoid with progestogenic and antiandrogenic properties, which is widely used for contraception and hormone replacement therapy. We investigated its potential role on adipocyte differentiation. The effects of DRSP were studied in murine preadipocyte cell lines and primary cultures of human preadipocytes. Differentiation markers and mechanisms underlying phenotypic variations in response to DRSP were explored. Early ex- posure to DRSP during differentiation led to a marked dose-depen- dent inhibition of adipose differentiation and triglyceride accumu- lation in 3T3-L1 and 3T3-F442A cells.