Sunitinib-Induced Hypothyroidism Is due to Induction of Type 3 Deiodinase Activity and Thyroidal Capillary Regression

Mari?tte H. W. Kappers; Joep H. M. van Esch; Frank M. M. Smedts; Ronald R. de Krijger; Karel Eechoute; Ron H. J. Mathijssen; Stefan Sleijfer; Frank Leijten; A. H. Jan Danser; Anton H. van den Meiracker; Theo J. Visser

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Sunitinib-Induced Hypothyroidism Is due to Induction of Type 3 Deiodinase Activity and Thyroidal Capillary Regression

机译：舒尼替尼诱导的甲状腺功能减退症是由于3型脱碘酶活性的诱导和甲状腺毛细血管的退缩。

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Context:Anticancer treatment with the tyrosine kinase inhibitor sunitinib causes thyroid dysfunction.

机译：背景：酪氨酸激酶抑制剂舒尼替尼的抗癌治疗引起甲状腺功能障碍。

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《The journal of clinical endocrinology and metabolism》 |2011年第10期|共8页
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Mari?tte H. W. Kappers; Joep H. M. van Esch; Frank M. M. Smedts; Ronald R. de Krijger; Karel Eechoute; Ron H. J. Mathijssen; Stefan Sleijfer; Frank Leijten; A. H. Jan Danser; Anton H. van den Meiracker; Theo J. Visser;
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1. Sunitinib-Induced Hypothyroidism Is due to Induction of Type 3 Deiodinase Activity and Thyroidal Capillary Regression [J] . Mari?tte H. W. Kappers, Joep H. M. van Esch, Frank M. M. Smedts, The journal of clinical endocrinology and metabolism . 2011,第10期

机译：舒尼替尼诱导的甲状腺功能减退症是由于3型脱碘酶活性的诱导和甲状腺毛细血管的退缩。
2. Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems. [J] . Guadano Ferraz-A, Escamez MJ, Rausell E, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 1999,第9期

机译：在甲状腺功能低下的大鼠大脑中2型碘甲状腺素脱碘酶的表达表明甲状腺激素在特定的初级感觉系统发育中的重要作用。
3. Effect of propylthiouracil-induced hypothyroidism on thyroid hormone profiles and tissue deiodinase activity in cashmere goats. [J] . Villar D, Rhind SM, Dicks P, Small Ruminant Research . 1998,第3期

机译：丙硫氧嘧啶引起的甲状腺功能减退对绒山羊山羊甲状腺激素谱和组织脱碘酶活性的影响。
4. Left Ventricular Myocardial Infarction in Mice Induces Sustained Cardiac Deiodinase Type III Activity [C] . C. Pol, M. Zuidwijk, E. Deel, International Society for Heart Research . 2008

机译：小鼠左心室心肌梗死诱导持续的心脏脱碘酶III型活性
5. EFFECTS OF THYROTROPIN RELEASING HORMONE AND ENVIRONMENTAL TEMPERATURE ON THE HYPOPHYSIAL-THYROID AXIS OF HYPOTHYROID, EUTHYROID AND CASTRATED WHITE LEGHORN CHICKENS [D] . CARR, BRUCE LESLIE 1981

机译：甲状腺素释放激素和环境温度对甲状腺素，乙状体和结扎的白羊腿雏鸡的垂体-甲状腺轴的影响
6. Expression of Type 2 Iodothyronine Deiodinase in Hypothyroid Rat Brain Indicates an Important Role of Thyroid Hormone in the Development of Specific Primary Sensory Systems [O] . Ana Guadaño-Ferraz, Maria José Escámez, Estrella Rausell, 1999

机译：甲状腺功能低下大鼠脑中2型碘甲状腺素脱碘酶的表达表明甲状腺激素在特定的主要感觉系统发育中的重要作用
7. Sunitinib-Induced Hypothyroidism Is due to Induction of Type 3 Deiodinase Activity and Thyroidal Capillary Regression [O] . Mariëtte H. W. Kappers, Joep H. M. van Esch, Frank M. M. Smedts, 2011

机译：Sunitinib诱导的甲状腺功能减退症是由于诱导3型Dei联酶活性和甲状腺毛细血管回归
8. Neonatal Screening for Congenital Hypothyroidism and Primary TSH (Thyroid Stimulating Hormone) Screening for Congenital Hypothyroidism [R] . Foley, T. P. , Murphy, W. H. 1981

机译：新生儿筛查先天性甲状腺功能减退症和原发性TsH（甲状腺刺激素）筛查先天性甲状腺功能减退症

Sunitinib-Induced Hypothyroidism Is due to Induction of Type 3 Deiodinase Activity and Thyroidal Capillary Regression

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