Normal Insulin-Like Peptide-3 Levels Despite Low Testosterone in Adult Males with Prader-Willi Syndrome: Variations in Leydig Cell Function from Infancy through Adulthood

摘要

Background:Cryptorchidism, incomplete pubertal development, and low testosterone are manifestations of hypogonadism in Prader-Willi syndrome (PWS). Insulin-like peptide-3 (INSL3) facilitates testicular descent in the fetus and reflects Leydig cell number in adults. INSL3 levels in PWS have not been previously reported.