Neuropilin-2 Expression in Papillary Thyroid Carcinoma: Correlation with VEGF-D Expression, Lymph Node Metastasis, and VEGF-D-Induced Aggressive Cancer Cell Phenotype

摘要

Context:Neuropilin-2 (Nrp2) is a coreceptor for vascular endothelial growth factor-D (VEGF-D) that is expressed on the surface of endothelial cells. Recently, Nrp2 was shown to play a role in lymph node metastasis and promotion of cancer cell migration. VEGF-D also promotes lymphangiogenesis, which in turn promotes tumor metastasis.