Response to Letter to the Editor: 'Androgens, Irregular Menses, and Risk of Diabetes and Coronary Artery Calcification in the Diabetes Prevention Program'.

摘要

dehydroepiandrosterone-sulfate (DHEAS) in miti- gating diabetes risk. Previous analyses in the Diabetes Prevention Program have examined the relationship between DHEAS and incident diabetes (1, 2), before and after adjustment for risk factors, including age. No as- sociation was seen before or after adjustment. It is pos- sible that DHEAS is associated with lower diabetes risk in populations with a wider range of body mass indices and levels of glucose tolerance. As for the role of DHEAS therapy, several randomized trials have not demonstrated noteworthy effects with DHEAS supplementation (3). It is possible that exogenous DHEAS concentrations have different metabolic effects than DHEAS produced by the adrenal glands.