Malakoplakia of the prostate diagnosed on multiparametric-MRI ultrasound fusion guided biopsy: A case report and review of the literature

摘要

Malakoplakia is an unusual chronic inflammatory condition described by Michaelis and Gutmann in 1902 and further characterized by von Hansemann in 1903.1 Microscopically, there are sheets of macrophages containing round concentrically basophilic intracytoplasmic inclusions (targetoid appearance) named Michaelis-Gutmann bodies; which contain calcium salts, iron, intact and degenerating bacteria within phagolysosomal bodies. A strong association with infectious process is well known, and a defective intraphagolysosomal digestive activity of macrophages and monocytes leading to inadequate killing of ingested bacteria is hypothesized. Gram-negative bacteria such as Escherichia coli and Klebsiella pneumonia are often isolated from malakoplakia lesions. However, association with immunosuppression has been linked too.1, 2.