Valida??o de métodos cromatográficos de análise: um experimento de fácil aplica??o utilizando cromatografia líquida de alta eficiência (CLAE) e os princípios da 'Química Verde' na determina??o de metilxantinas em bebidas

摘要

The validation of analytical methods is an important step in quality control. The main objective of this study is to propose an HPLC experiment to verify the parameters of validation of chromatographic methods, based on green chemistry principles, which can be used in experimental courses of chemistry and related areas.