Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and breast cancer risk in the Cancer de Màma (CAMA) study

摘要

Abstract Objective We investigated the association between adherence to the recommendations of the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and breast cancer (BC) risk in the Cancer de M??ma (CAMA) study in a Mexican population. Design Population-based casea€“control study. Subjects Incident BC cases (n 1000) and controls (n 1074) matched on age, region and health-care system were recruited. Setting In-person interviews were conducted to assess BC risk factors and habitual diet was assessed with an FFQ. Conformity to the WCRF/AICR recommendations was evaluated through a score incorporating seven WCRF/AICR components (body fatness, physical activity, foods and drinks that promote weight gain, plant foods, animal foods, alcoholic drinks and breast-feeding), with high scores indicating adherence to the WCRF/AICR recommendations. Results No statistically significant associations between WCRF/AICR score and risk of BC were observed. After excluding BMI from the WCRF/AICR score, the top quartile was associated with a decreased BC risk overall, with ORQ4a€“Q1=0?·68 (95 % CI 0?·49, 0?·92, P trend=0?·03), and among postmenopausal women, with ORQ4a€“Q1=0?·60 (95 % CI 0?·39, 0?·94, P trend=0?·03). Inverse associations were observed between BMI and risk of BC overall and among premenopausal women, with OR=0?·57 (95 % CI 0?·42, 0?·76, P trend