Management of locally advanced prostate cancer before the era of abiraterone/enzalutamide: A case study from India

摘要

This is a case presentation of a 57-year-old male patient treated for prostate cancer before the advent of novel agents such as abiraterone and enzalutamide. The patient presented with obstructive lower urinary tract symptoms in the year 2000. Digital rectal examination revealed hard enlarged prostate with mobile rectal mucosa. Prostate-specific antigen (PSA) was 36 ng/mL, transrectal ultrasound guided biopsy revealed S/O adenocarcinoma and a high Gleason score (4+3), CT scan of the pelvis found mild prostatomegaly with no LAP, and bone scan revealed no metastases. Radical prostatectomy was initially planned but was aborted when further examination revealed two enlarged lymph nodes and the frozen section was negative for malignancy. Despite being given hormonal agents and chemotherapy, his disease progressed, and the patient died in 2010 (Fig. 1).