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Comparison of analytical performance of i-Smart 300 and pHOx ultra for the accurate determination of pleural fluid pH

机译:i-Smart 300和pHOx ultra准确测定胸膜液pH的分析性能比较

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BackgroundPleural fluid pH is an essential test for diagnosing complicated parapneumonic effusion. We evaluated the performance of two blood gas analyzers in measuring pleural fluid pH.MethodsThe i-STAT G3+ (Abbott) was used as a reference analyzer to evaluate the pH values obtained from other methods: the i-Smart 300 (i-SENS), the pHOx Ultra (Nova Biomedical), using a clot catcher to filter off microclot, and pH indicator paper. Within-device precision was performed using quality control materials. We compared pleural fluid pH (n?=?86) by the above methods and analyzed the concordance rate at the level of the medical decision point, pH 7.2.ResultsThe within-device coefficient of variations of pH were below 0.1% for all blood gas analyzers tested. The slopes of the regression equations for the i-Smart 300, pHOx Ultra, and pH indicator paper against the reference analyzer were 0.850 (95% confidence interval, CI, 0.800–0.896), 0.714 (95% CI, 0.671–0.766), and 1.105 (95% CI, 0.781–1.581), respectively. The kappa values for the i-Smart 300, pHOx Ultra, and pH indicator paper against the reference analyzer were 0.883 (95% CI, 0.656–1.110), 0.739 (95% CI, 0.393–1.084), and 0.464 (95% CI, 0.102–0.826), respectively.ConclusionsThe i-Smart 300 and pHOx Ultra demonstrated good analytical performance and diagnostic accuracy when determining pleural fluid pH compared with that by the i-STAT G3+, whereas the pH indicator paper showed unsatisfactory results.
机译:背景胸水pH值是诊断复杂性肺炎旁积液的必不可少的测试。我们评估了两种血气分析仪在测量胸膜液pH值方面的性能。方法将i-STAT G3 +(Abbott)用作参考分析仪,以评估通过其他方法获得的pH值:i-Smart 300(i-SENS), pHOx Ultra(Nova Biomedical),使用凝块捕集器过滤微凝块和pH指示纸。使用质量控制材料执行设备内精度。我们通过上述方法比较了胸水的pH值(n?=?86)​​,并在医疗决策点pH 7.2的水平上分析了一致性率。结果所有血气的设备内pH变异系数均低于0.1%分析仪经过测试。 i-Smart 300,pHOx Ultra和pH指示纸相对于参考分析仪的回归方程的斜率分别为0.850(95%置信区间,CI,0.800-0.896),0.714(95%CI,0.671-0.766),和1.105(95%CI,0.781-1.581)。 i-Smart 300,pHOx Ultra和pH指示纸相对于参考分析仪的卡伯值分别为0.883(95%CI,0.656–1.110),0.739(95%CI,0.393–1.084)和0.464(95%CI)结论,分别为0.102–0.826)。结论与i-STAT G3 +相比,i-Smart 300和pHOx Ultra在测定胸膜液pH值时显示出良好的分析性能和诊断准确性,而pH试纸的结果却不尽人意。

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