Hierarchically Combined Periodic SERS Active 3D Micro- and Nanostructures for High Sensitive Molecular Analysis

摘要

To increase the local field intensity of Raman scattering, gold nanospheres were entrapped in gold coated periodic inverse pyramid structures, being SERS substrates by themselves. The applicability of this complex structure for sensitive molecule detection was proved by comparison of the detected Raman signals with and without particle entrapment. Moreover its relevance in molecular diagnostic was also proposed considering the specific surface functionalisation of the gold nanoparticles.