Factors influencing thrombin generation measured as thrombin-antithrombin complexes levels and using calibrated automated thrombogram in patients with advanced coronary artery disease

摘要

Introduction. Haemostatic factors play an important role in atherothrombosis. Thrombin generation is a crucial stage of blood coagulation. Objectives. Comparison of different thrombin generation markers: thrombin-antithrombin complex (TAT) generation and calibrated automated thrombogram method (CAT). Identification of factors influencing thrombin generation in patients with stable angina (SA) enrolled to the coronary artery bypass grafting (CABG) surgery. Analysis of traditional (age, gender, hypertension and diabetes) and novel (fibrinogen and C-reactive protein [CRP]) risk factors and the antiplatelet therapy (aspirin 75–150 mg/d) in relation to coagulation. Patients and methods. In 135 SA patients with left main coronary artery stenosis (>50%) or major epicardial artery stenosis (>70%), plasma TAT levels, maximal thrombin concentration (Cmax) and endogenous thrombin potential (ETP) were determined. A marker of the platelet activation (β-thromboglobulin) was also measured. Results. No correlations among TAT, Cmax, ETP, risk factors and β-thromboglobulin were observed. Linear regression model showed that independent predictors of TAT levels were age (β = 0.5; p =