Fibroblast growth factor 21, epidermal growth factor receptor, interleukin 6, myeloperoxidase, lipid hydroperoxide, apolipoproteins A-I and B, as well as lipid and lipoprotein ratios as diagnostic serum biomarkers for gastric cancer

摘要

Introduction Gastric cancer (GC) is a malignanttumor characterized by high rates of morbidityand mortality, which mainly results from the ab?sence of specific symptoms at early stages. Gas?tric cancer is classified according to a histologictype and the Lauren classification.1 For an indi?vidual assessment of prognosis and type of treat?ment, the histologic tumor grade along with eval?uation of the clinical stage is used. In GC, surgi?cal treatment remains the main therapeutic op?tion. Research suggests that combination thera?py improves the outcomes of treatment, althoughwith current chemotherapy regimens, responseto treatment is observed in 40% to 60% of cases.2It is important to search for methods that wouldidentify tumors sensitive to neoadjuvant treat?ment as well as examine the mechanisms respon?sible for resistance to oncologic treatment. Stud?ies have shown that fibroblast growth factor 21(FGF?21) levels are closely related to lipid metab?olism.3 It also plays a crucial role in maintainingproinflammatory/anti?inflammatory balance.