Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation

Derek S. Park; Afua A. Akuffo; David E. Muench; H. Leighton Grimes; Pearlie K. Epling-Burnette; Philip K. Maini; Alexander R. A. Anderson; Michael B. Bonsall

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Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation

机译：干细胞移植后潜在的克隆性造血作用及其对患者轨迹的影响

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Author summary We investigated the impact of clonal hematopoiesis of indeterminate potential on stem cell transplantation outcomes. Interclonal competition intensity was identified as an important determinant of ultimate hematopoietic trajectory. We also investigated the impact of age-related marrow changes and show that, from a mouse model, these ecological parameters can be estimated.

机译：作者摘要我们调查了潜力无限的克隆性造血对干细胞移植结果的影响。克隆间竞争强度被认为是最终造血轨迹的重要决定因素。我们还研究了与年龄有关的骨髓变化的影响，并表明，从小鼠模型中可以估算出这些生态学参数。

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《PLoS Computational Biology》 |2019年第4期|共28页
作者
Derek S. Park; Afua A. Akuffo; David E. Muench; H. Leighton Grimes; Pearlie K. Epling-Burnette; Philip K. Maini; Alexander R. A. Anderson; Michael B. Bonsall;
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中图分类细胞生物学;
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CloningStem cell nicheHematopoietic stem cellsBone marrow transplantationBone marrow cellsBone marrow stem cellsHematopoietic stem cell transplantationStem cell transplantation;

机译：克隆干细胞生境造血干细胞骨髓移植骨骨髓细胞骨髓干细胞造血干细胞移植干细胞移植;

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专利

1. Clonal hematopoiesis of indeterminate potential in older patients having received an allogeneic stem cell transplantation from young donors [J] . Heumueller Anezka, Wehrle Julius, Stosch Juliane, Bone marrow transplantation . 2020,第3期

机译：老年患者的克隆造血对来自年轻捐赠者的同种异体干细胞移植的老年患者不确定潜力
2. The Role of Clonal Hematopoiesis of Indeterminate Potential (CHIP) in Multiple Myeloma: Immunomodulator Maintenance Post Autologous Stem Cell Transplant (ASCT) Predicts Better Outcome [J] . Mouhieddine Tarek H., Park Jihye, Redd Robert A., Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：多发性骨髓瘤中不确定潜在（芯片）的克隆血液血液的作用：免疫调节剂维护后自体干细胞移植（ASCT）预测更好的结果
3. The Impact of Clonal Hematopoiesis of Indeterminate Potential on Survival in Patients with Newly Diagnosed Acute Myeloid Leukemia [J] . Sasaki Koji, Kanagal-Shamanna Rashmi, Montalban-Bravo Guillermo, Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：新诊断急性髓性白血病患者存活中不确定潜力的克隆血液血液的影响
4. Long-Term Support of Human Hematopoiesis by a Single Stem Cell Clone [C] . Toshiyuki Hirota, Junichi Nishimura, Yuzuru Kanakura, International Symposium on PNH and Related Disorders . 2003

机译：单个干细胞克隆人造血的长期支持
5. Donor selection for patients undergoing allogeneic hematopoietic stem cell transplantation: Assessment of the priorities of Canadian hematopoietic stem cell transplant physicians. [D] . Tay, Jason. 2009

机译：接受同种异体造血干细胞移植的患者的供体选择：加拿大造血干细胞移植医生的优先事项评估。
6. Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation [O] . Derek S. Park, Afua A. Akuffo, David E. Muench, 2019

机译：干细胞移植后潜在的克隆性造血作用及其对患者轨迹的影响
7. Clinical correlates and prognostic impact of clonal hematopoiesis in multiple myeloma patients receiving post‐autologous stem cell transplantation lenalidomide maintenance therapy [O] . Kitsada Wudhikarn, Leslie Padrnos, Terra Lasho, 2021

机译：克隆血液血管瘤在多发性骨髓瘤患者中临床关联及预后抗冲自体后干细胞移植性活性维持治疗
8. Antitheta-Sensitive Regulatory Cell (TSRC) and Hematopoiesis: Regulation of Differentiation of Transplanted Stem Cells in W/Wv Anemic and Normal Mice. [R] . Sharkis, S. J., Wiktor-Jedrzejczak, W., Ahmed, A., 1977

机译：抗癫痫敏感调节细胞（TsRC）和造血功能：调节W / Wv贫血和正常小鼠移植干细胞的分化。

Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation

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