Influence of the coating process parameters on the quality of PUR/PVP hydrogel coatings for PVC medical devices

摘要

Influence of the coating process parameters on the quality of PUR/PVP hydrogel coatings for PVC medical devicesTo decrease friction factor and enhance the biocompatibility of medical devices manufactured from poly(vinyl chloride), PVC, the surface modification with wear resistant polyurethane/polyvinylpyrrolidone (PUR/PVP) hydrogel coating can be applied. In the present work substrates were dip-coated with PVP and PUR solutions and thermally cured. The variable process parameters were: solvent system; concentration of polymers (1, 2 or 3% w/v); coating baths temperature (22, 38 and 55°C); drying temperature (32, 50 and 67°C); length of break between process steps (5, 30 and 90 s); and solutions storage time (up to 72 hrs). The quality of coatings was determined by friction coefficients against porcine aorta, weights of the deposited layer and the swelling capacity. The solvent system and polymers concentration were crucial factors. The increased temperature of coating solutions caused increased deposition but decreased durability. The most lubricious samples were dried in 50°C. Coatings from the solutions prepared 24h prior to use had better properties than those from fresh solutions.