Circadian leptin concentration changes in critically ill heart failure patients.

摘要

Physiologically, leptin concentration is controlled by circadianrhythm. However, in critically ill patients, circadian rhythm isdisrupted. Thus we hypothesized that circadian leptinconcentration changes are not preserved in critically ill patients.Ten consecutive critically ill heart failure patients with the clinicalindication for mechanical ventilation and sedation were includedinto our study. Plasma leptin concentration was measured every4 h during the first day (0-24 h) and during the third day(48-72 h) after admission. During the first day, there weresignificant leptin concentration changes (ANOVA, p0.05),characterized by an increase in concentration by 44 %(16-58 %); p=0.02 around noon (10 am-2 pm) and thena decrease in concentration by 7 % (1-27 %); p=0.04 in themorning (2 am-6 am). In contrast, there was no significantchange in leptin concentration during the third day afteradmission (ANOVA, p=0.79). Based on our preliminary results,we concluded that in critically ill heart failure patients, thecircadian rhythm of plasma leptin concentration seems to bepreserved during the first but not during the third day afteradmission.