Protective effects of Galium verum l. extract on the hypothalamic – pituitary – adrenal axis under anakinetic stress conditions, in rats. Histological aspects

摘要

24 female Wistar rats (120 ± 10 g) were divided into 4 groups: - control group (C); - Galium verum treated group (E), (25 mg extract/100 g bw); - anakinetic stressed group (S); - stress + Galium verum extract (25 mg extract/100 g bw) treated group (SE). Results revealed different reactivity of hypothalamo-hypophyseal-adrenal axis in the three experimental groups. The extract administration, in conditions of exposure to stress, resulted in an enhancement of NPV neurosecretory activity – associated with a possible stimulation of CRH release, a possible activation of adenohipophyseal hormones, as well as stimulation of adrenal steroid hormones. In S group, the effects of stress were opposite to those of E and SE groups. Histological results of the study proved that the administration of Galium verum vegetal extract in condition of anakinetic stress exposure induced important morphological changes at the all constitutive assembly of hypothalamo-hypophyseal-adrenal axis. These results justify the stimulation of secretory activity of the axis.