Here we analyzed associations between muscles mass, total bonemineral content (BMC), lumbar spine bone density (BMD L1-L4)and serum or urine hormones in healthy peripubertal girls. TotalBMC and areal BMD L1-L4, muscle mass and fat were measuredby dual-energy X-ray absorptiometry (DXA). Muscle force (N) wasestimated by a dynamometer. Circulating estradiol, folliclestimulatinghormone (FSH), luteinizing hormone (LH), 25-hydroxyvitamin D, parathyroid hormone (PTH), insulin-like growthfactor 1 (IGF-1), leptin, osteocalcin, bone isoenzyme of alkalinephosphatase (bALP) and total calcium and phosphorus werequantified as the nocturnal melatonin and serotonin urinaryexcretion. Partial correlations adjusted for height, Tanner scoreand physical activity confirmed positive relationships betweenBMC or BMD L1-L4 (Z-score) and lean mass or fat. Furthermore,positive relationship was observed between BMC or BMD L1-L4(Z-score) and serum leptin. After adjustment for Tanner scoreand physical activity, positive associations were observedbetween lean mass and IGF-1, leptin levels or muscle force. Weproved positive relationships between bone mass and serumleptin in peripubertal girls.
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