Experimental models of acute lung injury in the newborns.

摘要

Acute lung injury in the preterm newborns can originate fromprematurity of the lung and insufficient synthesis of pulmonarysurfactant. This situation is known as respiratory distresssyndrome (RDS). In the term neonates, the respiratoryinsufficiency is related to a secondary inactivation of thepulmonary surfactant, for instance, by action of endotoxins inbacterial pneumonia or by effects of aspirated meconium. Theuse of experimental models of the mentioned situations providesnew information on the pathophysiology of these disorders andoffers unique possibility to test novel therapeutic approaches inthe conditions which are very similar to the clinical syndromes.Herewith we review the advantages and limitations of the use ofexperimental models of RDS and meconium aspiration syndrome(MAS) and their value for clinics.