Vitamin D supplementation changed relationships, not levels of metabolic-hormonal parameters in autoimmune thyroiditis.

摘要

In women with chronic autoimmune thyroiditis and vitamin Ddeficiency we have found reference levels of relevant metabolichormonalparameters except for parathormone and total calcium.Three months supplementation with vitamin D (4300 IU/day,cholekalciferol) did not lead to significant changes of investigatedhormonal parameters, while the levels of parathormone andcalcium reached normal levels. However, a correlation analysisrevealed marked changes in mutual relations. First, an inversecorrelation of vitamin D with parathormone, insulin secretion(C peptide, insulin) and its efficiency (HOMA IR) disappeared.Relationships of vitamin D to hepatic insulin resistance(insulin/C peptide), to DHEA (both negative), and toDHEAS/DHEA ratio (positive) were newly found. Second,a positive correlation of CRP with insulin secretion remained,while its relation to insulin efficiency (HOMA IR, insulin/C peptide) was newly observed. Analogical positive correlationsappeared also among anti TPO and insulinemia,insulin/C peptide, HOMA IR, and anti Tg to C peptide.A relationship of the CRP with anti TPO became significant (+).Third, out of glucose metabolism parameters onlyinsulin/C peptide and glycemia did not correlate with vitamin Dduring its deficiency, while after supplementation insulin/C peptide alone correlated positively with both DHEAS and DHEA,and negatively with vitamin D.