Evaluation of left and right ventricular systolic and diastolic electromechanical synchrony in older people: a population-based observational study.

摘要

It is unknown whether physiological ageing also goes along withelectromechanical asynchrony of contraction. Aim of the studywas to evaluate synchrony of contraction in older people with(“non-healthy”) or without (”healthy”) evidence for structuralcardiac disease. In 547 persons (age 76.7±5.5 years, 306 male,241 female) recruited from a population-based cohort of theActiFE-Ulm study including a random sample of people ≥65 yearsold living in the region of Ulm, Germany, various PW- andTDI-Doppler based markers for asynchrony were obtained byechocardiography. Within a subgroup of 84 healthy subjects,at most minimal systolic and diastolic asynchrony was found.Concerning systolic asynchrony, similar observations were madewithin the non-healthy subgroup. However, extent of diastolic leftventricular intraventricular asynchrony and also – by tendency –diastolic interventricular asynchrony was increased in comparisonto the healthy subgroup. To conclude, no evidence thatphysiological ageing might go along with relevant left or rightventricular systolic or diastolic electromechanical asynchrony wasfound in our study. Furthermore, our population-based datasupport the results from other clinical studies with rather selectedcohorts that structural heart diseases might go along withincreased diastolic asynchrony.