Changes in omentin levels and its mRNA expression in epicardial adipose tissue in patients undergoing elective cardiac surgery: the influence of type 2 diabetes and coronary heart disease.

摘要

Omentin is a protein produced by numerous tissues includingadipose tissue. Its concentrations are decreased in patients withobesity, type 2 diabetes mellitus (DM) and coronary arterydisease (CAD). Experimental studies suggest that omentin mayhave anti-inflammatory and insulin-sensitizing properties. In thepresent study, we measured circulating omentin levels and itsmRNA expression in epicardial and subcutaneous fat, intercostaland heart muscle before and after elective cardiac surgery inpatients with CAD (CAD+, DM-, n=18), combination of CAD andDM (CAD+, DM+, n=9) or with none of these conditions (CAD-,DM-, n=11). The groups did not differ in baseline anthropometricand biochemical characteristics with the exception of higherblood glucose and HBA1c in CAD+, DM+ group. Baselinecirculating omentin levels tended to be lower in CAD+, DM- andCAD+, DM+ groups as compared to CAD-, DM- group andcardiac surgery increased its concentration only in CAD-, DMgroup.The change in serum omentin levels during surgeryinversely correlated with epicardial fat thickness. While baselineomentin mRNA expression did not differ among the groups in anyof the studied tissues, its increase after surgery was present onlyin subcutaneous fat in CAD-, DM- and CAD+, DM- groups, butnot in CAD+, DM+ group. Intercostal muscle omentin mRNAexpression increased after surgery only in CAD-, DM- group.In conclusion, cardiac surgery differentially affects omentin levelsand subcutaneous fat and skeletal muscle mRNA expression inpatients without coronary artery disease and diabetes ascompared to patients with these conditions.