Neonatal high protein intake enhances neonatal growth without significant adverse renal effects in spontaneous IUGR piglets

摘要

In humans, early high protein (HP) intake has been recommended to prevent postnatal growth restriction and complications of intrauterine growth restriction (IUGR). However, the impact of such a strategy on the kidneys remains unknown, while significant renal hypertrophy, proteinuria, and glomerular sclerosis have been demonstrated in few experimental studies. The objective of this study was to evaluate the effects of a neonatal HP formula on renal structure in IUGR piglets. Spontaneous IUGR piglets were randomly allocated to normal protein (NP, n ????=????10) formula or to HP formula (+50% protein content, n ????=????10) up to day 28 after birth. Body weight, body composition, renal functions, and structure were assessed at the end of the neonatal period. While birth weights were similar, 28?￠????day?￠????old HP piglets were 18% heavier than NP piglets ( P???? < ???? 0.01). Carcass protein content was 22% higher in HP than in NP offspring ( P???? < ???? 0.01). Despite a HP intake, kidney weight and glomerular fibrosis were unaltered in HP piglets. Only a 20% increase in glomerular volume was noted in HP piglets ( P ????