Propagermanium, a synthetic organic compound of germanium is known as β- or biscarboxyethylgermanium sesquioxide or Ge-132. It is found in some plants such as shelf fungus, ginseng, garlic, and Aloe vera. Ge-132 plays an important role for the pharmacological effects of the plants. The solubility of propagermanium at a certain pH is not exactly known yet. Until now, the analytical methods for the analysis of Ge-132 so far have the shortcoming and the propagermanium as germanium metal in the sample, so that improvement for propagermanium analysis was necessary to be conducted, primarily to be used for solubility assay. This study aims to determine the effects of pH on the propagermanium solubility using HPLC method for analysis. The results showed that validation parameters for analysis by using HPLC method e.i accuracy, precision, and linearity, have met to the quantitative analysis requirements. Increasing the pH causes increasing the solubility of propagermanium in the pH range of 3.0-3.6. The solubility result was 9.8514; 10.4204; 12.5446 mg/mL on pH 3.0; 3.3; 3.6.
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