An Inclusive Review on Analytical Methods for Ritonavir in Various Pharmaceutical and Biological Matrix

摘要

Background: Ritonavir (RTV) is an anti-retroviral drug used in the treatment of HIV/ AIDS. Many times, RTV is used alone and in combination with many anti retroviral drugs. So far, around seventy nine analytical methods have been reported for various studies on analysis of RTV in bulk, pharmaceutical formulations and biological fluids. Aim: To summarize the various analytical techniques such as Chromatography, Spectrophotometry; Capillary electrophoresis and also hyphenated techniques such as LC- MS/MS for estimation of Ritonavir. Method: The present article deals with the comprehensive details about the type of various analytical techniques such as Chromatography, Spectrophotometry; Capillary electrophoresis and also hyphenated techniques such as LC- MS/MS, and their applicability in analysis of RTV. These techniques are either explored for the quantification, detection of metabolite and also for stability-studies of the RTV. Conclusion: The present studies revealed that HPLC technique along with the spectroscopic have been most widely explored for the analysis. The investigatory review may provide the comprehensive details to the researchers who are working in the area of analytical research of RTV.