Thermal Versus Super Voltage Pulsed Radiofrequency of Stellate Ganglion in Post-Mastectomy Neuropathic Pain Syndrome: A Prospective Randomized Trial

摘要

Background: Breast cancer is the second most common cancer world-wide following lungcancer. Post-mastectomy pain syndrome (PMPS) is one of the chronic post-surgical pain disorders(CPSP) of neuropathic character; nearly 20–50% of patients may develop PMPS. Stellate ganglionblockade has been performed as a diagnostic, prognostic, or therapeutic intervention for differentpain syndromes.Objective: The aim of this study is to evaluate and compare the efficacy and safety of thermalversus super voltage pulsed radiofrequency (RF) application of stellate ganglion in neuropathicPMPS in cancer patients.Study Design: A prospective, double-blind, randomized, and controlled trial.Methods: Eighty patients with PMPS after surgery for breast cancer were recruited from the painclinic of the National Cancer Institute with pain duration of more than 6 months and less than 2years, visual analog scale (VAS) ≥ 40 mm, and not responding to oxycodone and pregabalin for atleast 4 weeks. The pain had to be of positive neuropathic character, as detected by the gradingsystem for neuropathic pain (GSNP; score of 3 or 4). The patients were allocated into 2 equallysized groups:Group A: Pulsed RF; super voltage pulsed RF was applied with a time of 360 seconds at 42o C, witha pulse width of 20 m/sec and voltage of 60–70 v.Group B: Thermal RF; thermal RF neurolysis was applied with a time of 60 seconds at 80o C, andwas then was repeated twice after needle-tip rotation. Stellate ganglion RF therapy was doneunder fluoroscopy, integrated by ultrasound guidance. The patients were assessed for pain reliefby change in VAS score, functional improvement, and the analgesic concomitant medication(oxycodone and pregabalin) consumption prior to block and at 1, 4, 12, and 24 weeks thereafter.The impact of treatment on quality of life (assessed by short-form health survey questionnaire [SF-36]) and patient function capacity (assessed by the Eastern Cooperative Oncology Group [ECOG])were also recorded.Results: The percentage of patients who had successful response was significantly higher in thethermal RF group compared to the pulsed RF group at the first week and first, third, and sixth months,with significant difference in post-mastectomy pain intensity, functional improvement, and less rescueanalgesia. There was no significant difference in quality of life or patient functional capacity.Limitations: A longer follow-up period may be needed for the evaluation of RF effect on PMPS.Conclusions: Thermal RF of the stellate ganglion is a safe and successful treatment for PMPS. Itappears to be more effective than pulsed RF of the stellate ganglion in this pain syndrome.