A comparison of total amount of blood needed in patients taking autologous or homologous blood transfusion in coronary artery bypass grafting: A Clinical Randomized Case-Control Trial

摘要

Objective: The aim of this clinical case-control trial was to compare the total amount of blood needed in patients taking autologous or homologous blood transfusion in coronary artery bypass grafting (CABG) surgery. Methodology: Sixty patients scheduled for CABG were randomly allocated to ANH (Acute Normovulemic Hemodynamic) group (A group) or control group (B group). Hematocrit before operation and 24 hours after the operation were checked. The amount of the total blood needed in each group was measured at the end of the operation. Result: There was no significant difference between the two groups as regards post operational hematocrit. The mean total blood infused to the control and ANH group was 2010ml and 1815ml respectively. However there was significant difference between the two groups as regards the total amount of the blood needed during operation. Conclusion: Our randomized, double blinded case control study demonstrated that autologous blood, beside carrying lower risks for hemolytic and nonhemolytic transfusion reactions decrease the total amount of blood needed for CABG. However larger studies with more patients are needed to confirm the results.