Occupational inequalities in female cancer incidence in Japan: Hospital-based matched case-control study with occupational class

摘要

Background Socioeconomic inequalities in female cancer incidence have previously been undocumented in Japan. Methods Using a nationwide inpatient dataset (1984–2016) in Japan, we identified 143,806 female cancer cases and 703,157 controls matched for sex, age, admission date, and admitting hospital, and performed a hospital-based matched case-control study. Based on standardized national classification, we categorized patients’ socioeconomic status (SES) by occupational class (blue-collar, service, professional, manager), cross-classified by industry sector (blue-collar, service, white-collar). Using blue-collar workers in blue-collar industries as the reference group, we estimated the odds ratio (OR) for each cancer incidence using conditional logistic regression with multiple imputation, adjusted for major modifiable risk factors (smoking, alcohol consumption). Results We identified lower risks among higher-SES women for common and overall cancers: e.g., ORs for managers in blue-collar industries were 0.67 (95% confidence interval [CI], 0.46–0.98) for stomach cancer and 0.40 (95% CI, 0.19–0.86) for lung cancer. Higher risks with higher SES were evident for breast cancer: the OR for professionals in service industries was 1.60 (95% CI, 1.29–1.98). With some cancers, homemakers showed a similar trend to subjects with higher SES; however, the magnitude of the OR was weaker than those with higher SES. Conclusions Even after controlling for major modifiable risk factors, socioeconomic inequalities were evident for female cancer incidence in Japan. Highlights ? Socioeconomic status is considered as a fundamental determinant for cancer risk. ? Occupational inequalities in female cancer incidence remain sparse in Japan. ? Higher-occupational class women had lower risks of stomach and lung cancer. ? Higher-occupational class women had higher risk of breast cancer. ? Even after controlling for major modifiable risk factors, the association remained.