The Cape Town declaration on human papillomavirus related disease

摘要

In 2017, we already have the knowledge and experience to prevent much of the human papillomavirus (HPV)-related disease burden globally. As a multidisciplinary research community, involving disciplines across the spectrum from basic science, epidemiology, vacci- nology and screening to public health, we have provided much of the evidence base that has been translated into highly effective public health programs around the world. Notably prophylactic HPV vaccination programs have already prevented HPV infections, genital warts and cervical pre-cancers in many countries. HPV based screening programs now have strong evidence to support their use as a more sensitive way to detect underlining cervical abnormalities, and we eagerly await the positive impacts of these emerging programs, which will be applicable in both unvaccinated and vaccinated populations. There is an imperative, with the tools now available, to provide every woman with access to effective cervical screening and every girl with access to prevention through vaccination. Access should be available irre- spective of where a girl or woman lives, her social status or whether she is immunocompromised. HPV-related cancers also affect men, and efforts to prevent HPV infection in men through HPV vaccination have the potential both to prevent many of these cancers and to reduce the risk of HPV transmission to sexual partners. The International Papillomavirus Society (IPVS) believes all countries should consider and promote national guidelines and programs to prevent HPV-related diseases, supported by international guidelines, access to international expertise and support for implementation through increased access to more affordable vaccines and screening technology (e.g. through revolving funds for vaccines). IPVS could be a bridge for these efforts.