Association ofTNF-857C>T,TNFRSF1A36A>G, andTNFRSF1B676T>GPolymorphisms with Ischemic Stroke in a Greek Population

摘要

Background. The role of genetic factors in the predisposition to develop ischemic stroke has been assessed by previous studies. The main goal of the current study was to determine any possible role ofTNF-857C>T,TNFRSF1A36A>G,andTNFRSF1B676T>Gpolymorphisms in risk for stroke.Materials and Methods. One hundred seventy-three patients with first ever ischemic stroke of solely atherosclerotic etiology in Northwest Greece and a control group of 179 healthy unrelated subjects were evaluated.Results.TNFα-857TT,TNFR136AA, andTNFR2676TTgenotypes were significantly increased in the patient group compared to controls (P=.008, OR = 2.47 (1.26–4.84),P=.005, OR = 1.97 (1.22–3.17), andP=.003, OR = 2.2 (1.43–3.37), resp.). In addition, theTNFR136Aand theTNFR2676Talleles were found significantly increased in patients compared to controls (P=.009, OR = 1.48 (1.1–2) andP=.001, OR = 1.75 (1.25–2.46), resp.).Conclusion. The high incidence of these genotypes and alleles in patient group suggests that they are potentially predisposing factors for stroke in the Greek population studied. Large-scale multicenter controlled studies are needed to verify these polymorphisms effects on stroke susceptibility.