Correlation between Interleukin 22 Serum Level and Severity of Psoriasis

摘要

Objectives: to study the Correlation between Interleukin 22 serum Level and severity index of Psoriasis Background : Interleukin-22 is a member of the IL10 cytokine family, described as having proinflammatory activites on liver, pancreas, intestine and skin. Material and Methods: The study was don on 45 subjects. These included 30 cases with chronic plaque psoriasis & 15 age- and sex-matched healthy individuals. All Patients were subjected to history taking and complete medical examination. Serum levels of IL-22 were measured by ELISA technique. Serum levels of IL-22 were statistically analyzed in relation to psoriasis area and severity index (PASI). Results: The serum levels of IL-22 was highly elevated in psoriasis patients compared with healthy people The serum IL-22 was significantly higher in patients with severe psoriasis as compared with those with mild and moderate psoriasis. The serum levels of IL-22 was higher in patients with long duration of psoriasis compared with recent psoriatic patients. Conclusion: IL-22 is involved in psoriasis. There is significant positive correlation between IL-22 serum levels and each of duration of psoriasis and PASI.