白细胞介素22在HBV相关性肝病中的表达及意义

摘要

目的：探讨白细胞介素22在HBV相关性肝病中的表达及意义。方法：酶联免疫法检测30例慢性乙型肝炎无症状携带者（ASC）、40例慢性乙型肝炎活动期（CHB）患者、45例慢性乙型肝炎后肝硬化（LC）患者、30例原发性肝癌（HCC）患者、25例健康对照者外周血清中IL-22水平。分析IL-22与肿瘤标志物AFP的相关性。结果：CHB组、LC组、HCC组外周血IL-22水平均高于对照组（P=0.010、0.003、0.000）。外周血清IL-22水平与AFP之间无相关性。结论：IL-22可能在肝脏慢性纤维化、肝癌发生方面可能起一定作用。%Objective:To explore the expression and significance of IL-22 in HBV related liver diseases. Method:Whole vein blood was obtained from healthy control(HC)(n=25)and experimental groups including the patients with asymptomatic carrier(ASC)(n=30),chronic hepatitis B(CHB)(n=40),liver cirrhosis(LC)(n=45), hepatocellular carcinoma(HCC)(n=30).The level of serum IL-22 were analysed by ELISA.Statistical analysis of the relevance of IL-22 levels and AFP was performed.Result:IL-22 level in the CHB group,LC group, and the HCC group were higher than that in the healthy control (P=0.010,0.003,0.000).IL-22 levels had no correlation with AFP. Conclusion:IL-22 may contributed to the occurrence and the development of liver fibrosis and hepatocellular carcinoma.