Factors Affecting Axillary Lymph Node Involvement in Breast Cancer

摘要

Objectives : to detect factors affecting axillary lymph node (LN) metastasis in breast cancer. Background: Surgical dissection is the accepted mode of staging the axilla in breast cancer. However, the associated morbidity has led researchers to look at less invasive options so Proper prediction of factors influencing axillary lymph node positivity is very important to detect proper surgical interference Methods: This study is a prospective, comparative, randomized and descriptive study it includes 40 patients Certain factors related to the primary tumor recorded including: (tumor size, lymphovascular invasion, body mass index (BMI), family history, histologic type, tumor grade and positivity or negativity for estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor 2 HER2neu ) and relation between these factors and percentage of positive axillary lymph nodes recorded. Results: there are factors that are highly predicator of axillary lymph node metastasis in breast cancer as age of patient of (p value 0.048) tumors larger than 2cm (p value 0.048). With positive lymphovasularinvasion (p value 0.036). Her 2neu positive tumors (p value 0.011) at upper outer quadrant (p value 0.008) obese patient (p value 0.046). Tumorhistopathology. Conclusion: young patients with tumors larger than 2cm with positive lymphovasular invasion Her 2neu positive tumors at upper outer quadrant obese patient tumor lobular carcinoma and mixed ductal and lobular have higher incidence of positive axillary lymph nodes so these factors should be considered in treatment. [ Ayman A. Albatanony, Asem F. Moustafa and Ali G. Hydara. Factors Affecting Axillary Lymph Node Involvement in Breast Cancer.