In Vivo Study of BPA (boron¹⁰-phenilalanine) Use in Boron Neutron Capture Radiotherapy as an Alternative for Hepatic Cancer Treatment

摘要

Since the response at conventional chemo- and radiotherapy treatment of hepatocellular carcinoma is extremely reduced, the research of the specialists from this domain were oriented to find new alternative therapies to assure a better response to the treatment of primary or metastatic liver tumors. The neutron capture by Boron-10 radiotherapy is a therapeutic method being in the pioneer's work stage especially in Europe, but with promising results, especially in brain tumor so far. The 10 Boron neutrons capture are producing alpha energetic particles, with a high linear energetic transfer at tissue level. Consequently it obtains higher cell destruction and greater biological relative efficiency than in the case of photons. Using adequate Boron compounds, preferentially localized in tumor cells and not in the healthy tissue, the Boron neutrons capture therapy gives a higher curative potential with lower toxicity in normal tissues. The aim of our study is to establish one in vivo experimental model which offer results that can be extrapolate at clinical level, because in our country this therapy was not approached yet. The first step was to establish the Boron-10 carrier compound and it's characteristics and also the characterization of its administration at tumor bearing rats. We investigate the solubility; the administration and the even toxicity induced by bor-phenilalanine.