Estudo imunobiológico de estoques de Trypanosoma cruzi isolados de pacientes na fase aguda da doen?a de Chagas

摘要

Ten stocks of trypanosomes isolated from patients at the acute phase of Chagas'disease were injected into groups of outbred normal mice at the doses of 103, 104 and 10s5 parasites/mouse and the course of the infections followed up for 3 months. The parasitemia was usually low, with recurrent peaks, the animals evolving to chronicity, only one of them inducing high ratio of mortality. Pattems of parasitemia and mortality were essentially different for each stock studied; only one stock did show similar pattems to well known strains (Yand CL) commonly used in experimental work. Parasites and lesions, although detected at the peak of parasitemia and restricted to heart were absent after three months. At this period the Igs profiles showed striking differences with respect to their distribution. Groups of mice that had been inoculated with one of the stocks were challenged with the Y or CL strains. In some instances low parasitemias although patent were seen after the infecting dose.